Oligonucleotides Therapeutics Xchange - Boston - 2026

Peptides CMC
- Peptides CMC
15:45 16:45

Building strategic CDMO partnerships for next-gen peptide therapeutics
Oligonucleotides R&D
- Oligonucleotides R&D
15:10 15:40

Poster Presentation: Thiophosphoramidate Morpholino Oligonucleotides (TMOs): A Novel Class of PMOs compatible With Conventional Automated Oligonucleotide Synthesis
Oligonucleotides CMC
- Oligonucleotides CMC
11:25 12:25

Building scalable, economically viable oligonucleotide manufacturing platforms: Overcoming the CMC bottlenecks for late-stage and commercial supply
Peptide R&D
- Peptides R&D
11:25 12:25

Navigating sequence optimization: leveraging AI, structure-based design, and multi-parameter tradeoffs
Peptides CMC
- Peptides CMC
09:05 10:05

Improving hit-to-lead transition: balancing potency, solubility, and manufacturability
Peptide CMC
- Peptides CMC
15:10 15:40

Poster Presentation: Digitalization in peptide CMC: leveraging AI, automation, and advanced analytics for competitive advantage
Peptides R&D
- Peptides R&D
15:10 15:40

Poster Presentation: Peptide-Enhanced AAV Delivery and AAV-Extended Long-Acting: Advancing Precision in Gene Therapy
Oligonucleotide CMC
- Oligonucleotides CMC
09:05 10:05

CMC Analytical Considerations and Challenges for Oligonucleotides and Oligonucleotide-conjugates

Analytical techniques, considerations and gaps supporting oligonucleotide and oligonucleotide-conjug ...

Hongling Han, , Senior Director, Head of Analytical Development and QC - PepGen
Oligonucleotides R&D
- Oligonucleotides R&D
09:05 10:05

Expanding the Reach of Oligonucleotide Therapeutics: Innovations in Receptor-Mediated and Targeted Delivery Topic TBC
Peptides R&D
- Peptides R&D
09:05 10:05

Regulatory & CMC path for peptides: bridging preclinical to clinic with quality and control
Peptides CMC
- Peptides CMC
11:25 12:25

Beyond the molecule: integrating drug product formulation and delivery into peptide CMC strategy
Peptides R&D
- Peptides R&D
15:45 16:45

Increasing in vivo half-life: strategies like cyclization, PEGylation, lipidation, albumin binding
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
15:00 15:10

Afternoon Refreshments
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
14:00 14:30

1-2-1 Meetings/Networking Break
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
16:45 17:45

Evening Drinks Reception
Oligonucleotide CMC
- Oligonucleotides CMC
15:10 15:40

Poster Presentation: Future application of novel manufacturing oligonucleotide synthesis approaches and considerations for oligo-based conjugates.
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
13:25 13:55

Spotlight Presentation: PolyPeptide
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
14:30 15:00

1-2-1 Meetings/Networking Break
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
08:30 09:00

Opening Address & Keynote Presentation:
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
12:25 13:25

Networking Lunch
Oligonucleotides R&D
- Oligonucleotides R&D
11:25 12:25

Bridging discovery to first-in-human: Overcoming translational bottlenecks for new oligonucleotide drug classes
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
11:15 11:25

Morning Refreshments
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
10:45 11:15

1-2-1 Meetings/Networking Break
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
10:10 10:40

1-2-1 Meetings/Networking Break
- Oligonucleotides R&D
- Oligonucleotides CMC
- Peptides R&D
- Peptides CMC
08:00 08:30

Registration
Oligonucleotide CMC
- Oligonucleotides CMC
15:45 16:45

Future application of novel manufacturing oligonucleotide synthesis approaches and considerations for oligo-based

Overview of current and advanced delivery technologies such as LNP, AAV, conjugations, polymeric etc ...

Harsh Chauhan, Director, Formulation Development and External Manufacturing - Alltrna
Oligonucleotides R&D
- Oligonucleotides R&D
15:45 16:45

Unlocking broader therapeutic applications of siRNA through innovative delivery strategies