Peptide and oligonucleotide therapeutics present distinct development challenges, including tissue penetration, cellular uptake, and confirmation of target engagement within complex biological environments. AmberGen provides drug-inclusive spatial mapping services that measure therapeutic distribution within intact tissue while simultaneously profiling five complementary molecular layers—proteins, RNA, lipids, metabolites, and glycans—from the same section. This integrated framework enables direct alignment of regional drug exposure with disease-relevant biology. Using an AI-powered correlative analytics pipeline, we convert complex multiomic tissue data into actionable mechanistic insight, supporting target validation, pharmacodynamic assessment, and translational decision-making across advanced therapeutic development programs.