Advances in imaging to monitor oligonucleotide delivery and target binding
30 Apr 2026
Drug Delivery
- Which imaging modalities provide the most meaningful insight into tissue distribution and intracellular localization of oligonucleotides
- How can imaging data be correlated with pharmacology to distinguish delivery from functional target engagement
- What are the limitations of current labelling strategies, and how do they impact the interpretation of delivery data
- How early should imaging be incorporated into discovery and translational studies to guide delivery optimization
- What challenges remain in translating preclinical imaging readouts to clinical relevance