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Linker Design
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Toxicity & Off-Target Effects
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Toxicity & Off-Target Effects
What are the key antibody design considerations to maximize tumor delivery? How can bispecific targe
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Evening Drinks Reception
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Registration
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Linker Design
How do differences in the internalization pathway between tumor and normal cells contribute to the t
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Target Selection
Are ADCs based on bispecific or biparatopic antibodies more effective in enhancing target cell bindi
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Afternoon Refreshments
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Antibody-drug conjugates (ADCs) are transforming oncology drug development by enabling targeted deli
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Networking Lunch
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Toxicity & Off-Target Effects
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Toxicity & Off-Target Effects
General: How do the targeting mechanisms of BsADCs, BpADCs, and TCRm-ADCs fundamentally differ in ac
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Toxicity & Off-Target Effects
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Toxicity & Off-Target Effects
Clinical Utility & Targeting How do we determine which patients are most likely to benefit from ADCs
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Morning Refreshments
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Cytotoxic Payload
How do you optimize payload potency and DAR for specific target receptors and disease indications? H
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Linker Design
Balancing Stability and Release: Ensuring the linker remains stable until reaching the target site w
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Target Selection
What is the target expression level? How efficient is internalization? Is there tumor or tissue sp
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Off-target binding is a significant hurdle in the development of antibody-based therapies, contribut
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Antibody-drug conjugates (ADCs) are transforming oncology drug development by enabling targeted deli ...
)
Off-target binding is a significant hurdle in the development of antibody-based therapies, contribut ...
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