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Toxicity & Off-Target Effects
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Toxicity & Off-Target Effects
What are the key antibody design considerations to maximize tumor delivery? How can bispecific targe
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Cytotoxic Payload
The development of dual-payload antibody-drug conjugates (ADCs) represents a cutting-edge approach t
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Networking Lunch
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Evening Drinks Reception
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Linker Design
How do differences in the internalization pathway between tumor and normal cells contribute to the t
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Target Selection
Are ADCs based on bispecific or biparatopic antibodies more effective in enhancing target cell bindi
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Target Selection
Antibody-drug conjugates represent a promising class of targeted cancer therapies, offering the pote
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Afternoon Refreshments
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Registration
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Toxicity & Off-Target Effects
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Toxicity & Off-Target Effects
What are the primary mechanisms driving ADC toxicity, and how can they be mitigated? How can we impr
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Target Selection
What are the key criteria for selecting the ideal ADC target, and how do we balance tumor specificit
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Morning Refreshments
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Cytotoxic Payload
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Linker Design
Balancing Stability and Release: Ensuring the linker remains stable until reaching the target site w
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
1-2-1 Meetings / Networking Break
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Target Selection
What is the target expression level? How efficient is internalization? Is there tumor or tissue sp
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Target Selection
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Toxicity & Off-Target Effects
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Linker Design
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Cytotoxic Payload
Off-target binding is a significant hurdle in the development of antibody-based therapies, contribut
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Off-target binding is a significant hurdle in the development of antibody-based therapies, contribut ...
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