Optimizing target selection for next-generation antibody-drug conjugates to enhance efficacy and safety
18 Jun 2025
Target Selection
- What are the key criteria for selecting the ideal ADC target, and how do we balance tumor specificity, expression levels, and accessibility?
- How can emerging biomarkers and novel antigens expand the landscape of ADC development?
- What are the biggest challenges in target validation, and how can we address tumor heterogeneity, resistance mechanisms, and on-target toxicity?
- How can we improve tumor penetration and optimize payload delivery to enhance ADC efficacy?
- What lessons can we learn from past ADC successes and failures to refine target selection strategies?