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Optimizing target selection for next-generation antibody-drug conjugates to enhance efficacy and safety

18 Jun 2025
Target Selection
  • What are the key criteria for selecting the ideal ADC target, and how do we balance tumor specificity, expression levels, and accessibility?
  • How can emerging biomarkers and novel antigens expand the landscape of ADC development?
  • What are the biggest challenges in target validation, and how can we address tumor heterogeneity, resistance mechanisms, and on-target toxicity?
  • How can we improve tumor penetration and optimize payload delivery to enhance ADC efficacy?
  • What lessons can we learn from past ADC successes and failures to refine target selection strategies?