Crafting the optimal linker: Leveraging insights from the past to innovate for target-specificity, format-compatibility, indication alignment, and payload efficacy
18 Jun 2025
Linker Design
- Balancing Stability and Release: Ensuring the linker remains stable until reaching the target site while enabling effective payload release at the right moment.
- Target-Specificity Conflicts: Designing optimal linkers for heme vs solids vs stromal
- Compatibility with Various Formats: Is there opportunity or challenges in designing the linker tailored to PK, penetration and biodistribution
- Optimizing Payload Potency: Ensuring the linker supports maximum therapeutic impact of the payload without compromising safety.
Industry Expert
