Mitigating toxicity and off-target effects in antibody-drug conjugates for safer and more effective therapies
18 Jun 2025
Toxicity & Off-Target Effects
- What are the primary mechanisms driving ADC toxicity, and how can they be mitigated?
- How can we improve linker stability and payload release to minimize off-target effects?
- What strategies can enhance tumor selectivity while reducing systemic toxicity?
- How can translational models and biomarkers help predict and manage ADC-related toxicities?