Bispecific-, Biparatopic-, and T-cell receptor mimic ADCs: New players to mitigate off-target effects?
18 Jun 2025
Toxicity & Off-Target Effects
- General: How do the targeting mechanisms of BsADCs, BpADCs, and TCRm-ADCs fundamentally differ in achieving tumor selectivity?
- BsADCs: How critical is the spatial proximity and co-expression of two antigens for BsADC function?
- BpADCs: How does dual-epitope targeting impact internalization efficiency?
- TCRm-ADCs: How can we mitigate the risks of off-target cross-reactivity in TCRm-ADC development? Are TCRm-Abs a realistic opportunity for ADCs?
Industry Expert
