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Mitigating toxicity and off-target effects in antibody-drug conjugates for safer and more effective therapies

18 Jun 2025
Toxicity & Off-Target Effects
  • What are the primary mechanisms driving ADC toxicity, and how can they be mitigated?
  • How can we improve linker stability and payload release to minimize off-target effects?
  • What strategies can enhance tumor selectivity while reducing systemic toxicity?
  • How can translational models and biomarkers help predict and manage ADC-related toxicities?