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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
1-2-1 Meetings / Networking Break
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ADC Linker Design & Conjugation Technologies
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ADC Linker Design & Conjugation Technologies
AJICAP® is a proprietary platform combining site-specific conjugation technology with a novel hydrop
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Formats & Scaffolds
AI-driven protein and antibody design platforms can rapidly generate large candidate sets, but timel
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Target Selection & Mechanisms of Action
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Target Selection & Mechanisms of Action
Traditional drug discovery is heavily bottlenecked by the slow, iterative process of translating dis
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Bi/Multispecifics
Camelid immunization has long been viewed as a slow, unpredictable path to VHH discovery, particular
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ADC Linker Design & Conjugation Technologies
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ADC Linker Design & Conjugation Technologies
How much of ADC linker selection is rational design versus platform default, and how rigorously are
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Track antibody and ADC programs by leveraging CDD Vault’s chemically aware macromolecule capabilitie
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ADC Cytotoxic Payload
Are topoisomerase I inhibitor (TOP1i) payloads the default for solid tumor ADCs, or is the field ove
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ADC Cytotoxic Payload
Why do some ADCs achieve significant efficacy with manageable toxicity while others fail despite tar
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ADC Linker Design & Conjugation Technologies
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ADC Linker Design & Conjugation Technologies
How is the ADC space continuing to grow, and why does it remain heavily focused on similar payload t
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Target Selection & Mechanisms of Action
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Linker Design & Conjugation Technologies
In silico and in vitro immunogenicity assessment as a de-risking strategy Approaches to mitigate the
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Formats & Scaffolds
What are best formats for different functions? Examples: AND gate, OR gate, affinity/avidity tuning.
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Bi/Multispecifics
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Lead Identification & Optimization
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Lead Identification & Optimization
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Formats & Scaffolds
How do symmetric vs. asymmetric vs. fragment-based architectures trade off manufacturability, stabil
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Lead Identification & Optimization
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Lead Identification & Optimization
Many antibody discovery campaigns still measure success by the number of binders recovered, but high
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Lead Identification & Optimization
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Lead Identification & Optimization
The SpyCatcher-SpyTag reaction is a fast, specific method to covalently link two proteins. We develo
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Formats & Scaffolds
How have intracellular proteins historically been accessed by antibody therapeutics? How can intrace
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Bi/Multispecifics
What has CAR-T already taught us about the biology of durable responses in autoimmune diseases beyon
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Lead Identification & Optimization
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Lead Identification & Optimization
Why many “best-in-class” binders still fail clinically The industry shift from affinity optimization
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Antibody-based therapeutics generated with current technologies inherently exhibit product heterogen
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Bi/Multispecifics
Which developability assays are most informative for assessing candidates early on? -for stability,
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Drinks-Canape Reception
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Afternoon Refreshments
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
1-2-1 Meetings / Networking Break
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
1-2-1 Meetings / Networking Break
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Networking Lunch
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Morning Refreshments
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
1-2-1 Meetings / Networking Break
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
1-2-1 Meetings / Networking Break
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Many high-value membrane protein targets, including GPCRs and ion channels, have remained untapped f
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Bi/Multispecifics
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Formats & Scaffolds
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Target Selection & Mechanisms of Action
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ADC Linker Design & Conjugation Technologies
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ADC Cytotoxic Payload
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Lead Identification & Optimization
Registration