Careful selection of building block properties and compatibility essential to boost the overall success of multispecifics
03 Nov 2026
Formats & Scaffolds
- When you screen building blocks individually, what predicts (or fails to predict) how they'll behave once combined?
- How do you decide format before knowing your final pairing — or does format selection happen iteratively?
- What's a compatibility failure mode you didn't see coming until late-stage development?
- Is there a "universal" scaffold, or is format selection always going to be target/biology-specific?
- How much should manufacturability constraints shape building-block choice upstream, versus optimizing for potency first and fixing developability later?
