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Oligonucleotides & Peptides Xchange - San Francisco - 2026

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08:00
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Registration
08:30
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Opening Address & Keynote Presentation:
09:05
  1. Peptide Discovery & Design
    • Peptide Discovery & Design
    Re engineering endogenous and natural peptides into viable therapeutics, strategies to improve stability and selectivity while preserving biological function
  2. Peptide Delivery & Targeting
    • Peptide Delivery & Targeting
    Improving cellular uptake of peptide therapeutics, strategies to overcome membrane permeability and endosomal trapping
  3. Peptide CMC & Manufacturing
    • Peptide CMC and Manufacturing
    Managing solid phase peptide synthesis limitations for long and complex sequences, addressing coupling inefficiencies, deletions, and sequence dependent failure modes
  4. Oligonucleotide Delivery
    • Oligonucleotide Delivery
    Engineering Ionizable Lipids and LNPs for Improved Oligonucleotide Delivery: From Endosome Escape to Biocompatibility
  5. Oligonucleotide CMC & Quality
    • Oligonucleotide CMC and Quality
    Purification bottlenecks after solid phase synthesis, strategies for managing highly impure or difficult oligonucleotides and conjugates
10:10
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    1-2-1 Meetings/Networking Break
10:45
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    1-2-1 Meetings/Networking Break
11:15
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Morning Refreshments
11:25
  1. Peptide Discovery & Design
    • Peptide Discovery & Design
    Sequence and structural design challenges in early stage peptide discovery, managing conformational flexibility, aggregation risk, and loss of activity during optimization
  2. Peptide Delivery & Targeting
    • Peptide Delivery & Targeting
    Targeted peptide delivery to specific tissues and cell types, leveraging receptor mediated uptake and tissue selective targeting approaches
  3. Peptide CMC & Manufacturing
    • Peptide CMC and Manufacturing
    Purification challenges for therapeutic peptides, strategies for separating closely related impurities and improving overall process yield
  4. Oligonucleotide Delivery
    • Oligonucleotide Delivery
    Engineering delivery systems for extrahepatic oligonucleotide delivery, addressing tissue specificity, cellular uptake, and functional activity beyond the liver
  5. Oligonucleotide CMC & Quality
    • Oligonucleotide CMC and Quality
    Ensuring robust QC processes during manufacturing and scaling
12:25
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Networking Lunch
13:25
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Spotlight Presentation:
       
14:00
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    1-2-1 Meetings/Networking Break
14:30
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    1-2-1 Meetings/Networking Break
15:00
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Afternoon Refreshments
15:10
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Spotlight Presentation:
15:45
  1. Peptide Discovery & Design
    • Peptide Discovery & Design
    Poster Presentation: Designing peptides for difficult and non traditional targets, including protein protein interactions and shallow or dynamic binding interfaces
  2. Peptide Delivery & Targeting
    • Peptide Delivery & Targeting
    Poster Presentation: Evaluating and comparing peptide delivery technologies, translating in vitro uptake and biodistribution data into in vivo relevance
  3. Peptide CMC & Process Development
    • Peptide CMC and Manufacturing
    Poster Presentation:Scaling peptide manufacturing from early development to commercial supply, ensuring process robustness and reproducibility
  4. Oligonucleotide Delivery
    • Oligonucleotide Delivery
    Poster Presentation: Measuring and interpreting biodistribution and target engagement for oligonucleotide therapeutics, translating preclinical delivery data into clinical relevance
  5. Oligonucleotide CMC & Quality
    • Oligonucleotide CMC and Quality
    Stability-Indicating Methods for Backbone-Modified Oligonucleotides: Degradation Pathways and Control Strategy
16:10
  1. Peptide Discovery & Design
    • Peptide Discovery & Design
    Applying computational and AI driven approaches to peptide design, practical impact on hit identification, sequence optimization, and structure activity relationship development
  2. Peptide Delivery & Targeting
    • Peptide Delivery & Targeting
    Assessing functional delivery of peptides to the CNS, linking brain exposure, target engagement, and pharmacodynamic response
  3. Peptide CMC & Process Development
    • Peptide CMC and Manufacturing
    Analytical and characterization challenges for complex and modified peptides, establishing meaningful specifications and stability indicating methods
  4. Oligonucleotide Delivery
    • Oligonucleotide Delivery
    Selecting and optimizing oligonucleotide delivery approaches during discovery, aligning chemistry, format, and screening models to enable downstream development
  5. Oligonucleotide CMC & Quality
    • Oligonucleotide CMC and Quality
    Advancing automation and digital systems in oligonucleotide manufacturing
17:10
    • Peptide Discovery & Design
    • Peptide Delivery & Targeting
    • Peptide CMC and Manufacturing
    • Oligonucleotide Delivery
    • Oligonucleotide CMC and Quality
    Drinks-Canape Reception
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