Nostrum Biodiscovery advances therapeutic discovery by seamlessly blending high-resolution, physics-based molecular modeling with advanced machine learning. Delivering built-in quantum accuracy, Nostrum's atomistic simulations evaluate complex chemical modification landscapes—such as backbone, sugar, and base variations—before synthesis. This physical grounding is directly accelerated by an internally developed suite of advanced AI tools: ChaRNABERT, a foundational RNA model; ASOFinder, which shortlists and ranks the most promising ASOs. Crucially, these unique predictive capabilities are fully integrated within our proprietary computational platform software toolkit to streamline and accelerate rational nucleic acid drug design.