Tackling protein aggregates: Optimising peptide purification processes
02 Dec 2025
CMC & Process Development
- What are the primary molecular interactions driving aggregate formation during peptide purification?
- How do solvent composition, pH, and temperature influence aggregation behavior and purification efficiency?
- Which chromatographic strategies or additives are most effective in reducing aggregate formation?
- Can analytical tools like DLS or SEC be leveraged to monitor and predict aggregation tendencies in real time?
- What emerging technologies or formulation approaches show promise for preventing aggregation in large-scale peptide manufacturing?
Industry Expert
