Immune metabolic pathways in maintaining tolerance
25 Sep 2025
Immune Regulation
- Recent advances in our understanding of immune cell metabolic pathways, and their driving role in inflammatory & autoimmune disease.
- Difficulties and barriers to translating preclinical work on immunometabolism to new therapies (training, tool access, and consensus on experimental models).
- Disconnect between in vitro models and in vivo immunometabolism.
- Learning from existing anti-inflammatory drugs targeting immune metabolic pathways.
- Moving beyond drugging immunometabolism with small molecules: new therapeutic modalities & delivery technologies on the horizon.
- Opportunities for targeting immunometabolism beyond anti-inflammatory therapeutics: improving efficacy of cell therapies, overcoming immune suppression in cancer, and targeting “fibrometabolism” in fibrotic disease.
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