Advancing neoantigen identification and immune monitoring: From discovery to clinical validation
25 Sep 2025
Immune Biomarkers
- Address the challenge of accurately predicting truly immunogenic neoantigens despite advances in AI and sequencing technologies.
- Discuss the difficulty of experimentally validating predicted neoantigens and distinguishing between patient-specific and shared targets.
- Explore the limitations in immune monitoring techniques for reliably tracking neoantigen-specific responses during treatment.
- Examine the translational hurdles in scaling and validating personalized neoantigen therapies for clinical use.
