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Implementing novel preclinical organoid and in vivo models to investigate subtype-selectivity and cross-species activity of CNS therapeutics.

24 Jun 2024
Salon B
  • For example, the PDE4 enzyme family consists of several subtypes & their isoforms with different expression pattern and functional roles.
  • How can we successfully test subtype mediated effects of subtype-selective compounds in preclinical species?
  • How can we overcome cross-species limitations, and challenges in targeting specific isoforms with differential expression & function in peripheral and CNS tissues
Industry Expert
Noah Druckenbrod, Assoc. Director Discovery - Decibel Tx