Implementing novel preclinical organoid and in vivo models to investigate subtype-selectivity and cross-species activity of CNS therapeutics.
24 Jun 2024
Salon B
Preclinical
- For example, the PDE4 enzyme family consists of several subtypes & their isoforms with different expression pattern and functional roles.
- How can we successfully test subtype mediated effects of subtype-selective compounds in preclinical species?
- How can we overcome cross-species limitations, and challenges in targeting specific isoforms with differential expression & function in peripheral and CNS tissues
Industry Expert
