The emerging receptor and transporter target landscape for drug delivery across the BBB — lessons learned and translational status
10 Sept 2026
Blood Brain Barrier
- What are the principal receptors and transporters currently being targeted for the delivery of proteins and AAV vectors across the BBB?
- What is known about how the various receptors and transporters targeted for delivery across the BBB differ with respect to overall expression, vessel location, and expected endocytic flux at the BBB?
- What is known about how the expression and function of these receptors and transporters vary across the lifespan and in disease?
- What is the translational status for the field currently?
- What knowledge gaps remain? How can they be addressed?
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