Spotlight Presentation: Olfactory Neurons as a Longitudinal, Molecular Window Into Patient Brain Biology
05 May 2026
Target Discovery
Disease Models
Novel Modalities
Blood Brain Barrier
Biomarkers in Discovery
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Human, longitudinal, neuronal data is absent in neuroscience due to the lack of direct access to the brain tissue. Crownlands creates such rich neuronal data by collecting olfactory neurons, CNS-linage neurons residing in nasal cavity which express 84% of brain-enriched genes and carry disease-relevant proteinopathy in a stage-relevant manner. Access to olfactory neurons at scale enables Crownlands to identify novel, potentially root-cause targets for neurodegenerative diseases, and to develop translational as well as patient stratification biomarkers.
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