Optimizing CNS penetration while minimizing systemic toxicity
05 May 2026
Blood Brain Barrier
• How can we leverage the protective and homeostatic functions of the blood–brain barrier to our advantage in delivering effective CNS therapies?
• How is our evolving understanding of receptor involvement and protein trafficking reshaping the way we think about the structure and function of the blood–brain barrier?
• How should variability in blood–brain barrier function—driven by factors such as age, sex, genetics, and physiological state inform the selection of appropriate models for preclinical testing?
• How can we best leverage in vitro BBB NAMs (2D and 3D)?
• How can selecting optimal routes of administration and delivery methods be used as a strategy to reduce systemic exposure?
• How is our evolving understanding of receptor involvement and protein trafficking reshaping the way we think about the structure and function of the blood–brain barrier?
• How should variability in blood–brain barrier function—driven by factors such as age, sex, genetics, and physiological state inform the selection of appropriate models for preclinical testing?
• How can we best leverage in vitro BBB NAMs (2D and 3D)?
• How can selecting optimal routes of administration and delivery methods be used as a strategy to reduce systemic exposure?
Industry Expert
