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Expanding efficacy while maintaining an acceptable therapeutic index

02 Sept 2026
ADC Cytotoxic Payload
  • Why do some ADCs achieve significant efficacy with manageable toxicity while others fail despite targeting the same antigen?
  • Which characteristics of target, antibody, linker, payload, and patient biology most strongly determine clinical success? 
Industry Expert
Paul Ponath, Director - Bolt Biotherapeutics