Learning from trillions: Towards de novo discovery of antigen-specific antibodies using AI and experimental feedback
22 Sep 2025
AI & Machine Learning
- Why does sequence-to-function prediction remain noisy and context-dependent?
- Why do naïve repertoires often lack sufficient diversity or affinity to known targets?
- How can we address the challenge of sparse experimental feedback relative to model complexity?
- How can models generalize across targets without overfitting?
- Why are disordered targets still challenging to work with?
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