Crafting the optimal linker: Leveraging insights from the past to innovate for target-specificity, format-compatibility, indication alignment, and payload efficacy
22 Sep 2025
ADC Linker Design & Conjugation Technologies
- What are the toxicities associated with traditional linker-platforms
- Next-generation linkers to balance stability, targeted payload release, and desired release mechanisms: When to use them?
- What are the Key developability levers? Cleavable vs non-cleavable, hydrophilicity engineering, TME-cleavable triggers, self-immolative spacer choice (PABC vs alternative) etc.
- What are the priority essays for evaluating ADC linkers? Plasma stability, lysosomal cleavage, cell potency-bystander, DAR distribution, hydrophobicity etc
