Reducing resistance of cancer cells to payloads
22 Sep 2025
ADC Cytotoxic Payload
- Resistance mechanisms to ADCs include drug exports and target mutations. What are we missing?
- Approved payloads revolved around the same 3 targets. How to expand the payload repertoire?
- Dual payload has been employed to minimise resistance. Given the limited number of options, is this a viable path?
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