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Reducing resistance of cancer cells to payloads

22 Sep 2025
ADC Cytotoxic Payload
  • Resistance mechanisms to ADCs include drug exports and target mutations. What are we missing?
  • Approved payloads revolved around the same 3 targets. How to expand the payload repertoire?
  • Dual payload has been employed to minimise resistance. Given the limited number of options, is this a viable path?
Industry Expert
Remi-Martin Laberge, Co-founder, CTO - Arda Therapeutics