Target selection to avoid off-target effect and cross-reactivity with healthy tissues
22 Sep 2025
Target Selection & Mechanisms of Action
- Is there a need for novel targets that can differentiate based on biology and overcome target-dependent drug resistance?
- Can targets expressed or presented on normal cells result in off-target toxicity?
- Is there a need for the ability to assess off-target effects on healthy tissue early in preclinical development?
- Are animal models and tissue cross-reactivity studies inapplicable or insufficient for some targets, potentially failing to provide relevant data?
- Is there increasing utility in using in vitro assays on healthy human cells as an early screen or even as an alternative to animal testing?
