Opening Address & Keynote Presentation: The Truth About Antibodies and Polyspecificity
22 Sept 2025
Bi/Multispecifics
Formats & Scaffolds
Target Selection & Mechanisms of Action
AI & Machine Learning
ADC Linker Design & Conjugation Technologies
ADC Cytotoxic Payload
Lead Identification & Optimization
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Off-target binding is a significant hurdle in the development of antibody-based therapies, contributing to both drug attrition and adverse events in patients. Recent analysis from our own work identified a surprisingly high off-target rate across the industry, with up to one third of antibody drugs displaying off-target binding. In this presentation, we will discuss the emergence of cell-based protein arrays, including the Membrane Proteome Array, as an alternative and improved technology to assess antibody specificity.
