Beyond bispecifics - how to select and optimize multispecific scaffolds?
22 Sep 2025
Formats & Scaffolds
- There are many parameters to optimize, especially when you get to 3+ binding moieties. which knobs are most valuable to turn?
- Are there generalizable scaffold lessons that are agnostic of the specific binding domains (e.g., CDR-agnostic rules of thumb)?
- It's hard to find formats that are as good as vanilla IgGs. what developability characteristics are okay to compromise on?
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