Beyond bispecifics - how to select and optimize multispecific scaffolds?
22 Sept 2025
Formats & Scaffolds
- There are many parameters to optimize, especially when you get to 3+ binding moieties. which knobs are most valuable to turn?
- Are there generalizable scaffold lessons that are agnostic of the specific binding domains (e.g., CDR-agnostic rules of thumb)?
- It's hard to find formats that are as good as vanilla IgGs. what developability characteristics are okay to compromise on?
Industry Expert
