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Novel strategies for optimizing antibody stability and half-life

19 Feb 2025
Lead Identification & Optimization
  • What are the key issues faced in the in vitro degradation of antibodies, and which (bio)chemical pathways contribute to their degradation ?
  • How can we identify optimal formulation conditions for antibodies, considering factors such as pH, temperature, and the use of excipients ?
  • What strategies can be employed to control and optimize the variability in glycosylation profiles of antibodies ?
  • In what ways can protein engineering, such as Fc domain modifications, contribute to enhanced antibody stability and half-life ?
  • How do antibodies interact with the immune system, and what mechanisms govern their clearance in vivo ?
Industry Expert
Alex Sevy, Director of Antibody Therapeutics - Aegis Life