Stop shooting in the dark: Leveraging early structural insights to power rational antibody lead design & optimization
19 Feb 2025
Lead Identification & Optimization
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- Why is gathering high-quality structural data in early screening critical to speeding up development and reducing late-stage failures?
- How do we “engineer in” affinity and stability while “engineering out” off-target effects or immunogenicity?
- What causes discrepancies between in vitro success and in vivo performance, and how can we minimize them?
- What best practices ensure early structural insights truly accelerate lead optimization?
- How can high-throughput PLIMB de-risk key decisions and help deliver more predictable in vivo outcomes?
- Where do advanced structural techniques fit into your current discovery pipeline?
Industry Expert
