What is the perfect workflow for generating antibody drug candidates?
28 Oct 2024
Lead Identification & Optimization
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- How many hits (binders) should be further analyzed?
- How to select candidates of interest? Which parameters are highly relevant?
- Developability assessment early on as a selection criterion or rather later for a smaller number of candidates?
- What are the main challenges: affinity, correct epitope, developability, pH specific binding, posttranslational modifications/mutations, challenging targets, functionality?
