Designing T-cell engagers for targeting pMHC
01 Mar 2027
Formats & Scaffolds
- How have intracellular proteins historically been accessed by antibody therapeutics?
- How can intracellular proteins, when presented as pMHC, be targeted by TCR and TCR-mimicking antibody-based therapeutics?
- What are suitable architectures for pMHC-targeting T-cell engagers (TCEs)?