Antibody affinity maturation strategies: Balancing potency, selectivity, and developability
01 Mar 2027
Lead Identification & Optimization
- Strategies for improving antibody affinity during lead optimization.
- How does antibody affinity influence internalization, efficacy, and pharmacokinetics?
- To what extent do CDX and PDX models reflect the tumor heterogeneity observed in patients?
- How can antibody affinity and epitope selection be optimized to maximize the therapeutic index?
- How can CDX and PDX models be leveraged to better predict clinical response and mechanisms of resistance?