Bispecific antibodies from an established modality to advanced modes of action
01 Dec 2025
Bi/Multispecifics
- How can bispecific antibodies be designed to achieve diverse modes of action such as antagonism, agonism, cell depletion, selectivity enhancement, and targeted tissue or cell delivery?
- What opportunities and challenges arise from using logic-gated molecules and conditional activation strategies?
- How can we best navigate format diversity in bispecifics, and what are the implications for CMC development and manufacturability?
- What translational strategies can demonstrate added value over single mechanisms of action, and how can potency assays be designed to reflect specific modes of action?
- How can the risk of immunogenicity be anticipated, assessed, and mitigated in next-generation bispecific constructs?
Industry Expert
