Lead discovery and optimisation of large molecules that bind to highly-charged targets
18 Nov 2024
Lead Identification & Optimization
- A preponderance of positively-charged residues (R, K) in the paratope of antibodies can lead to polyreactivity and polyspecificity – both phenotypes are unwanted.
- When targeting negatively-charged, target protein patches, you can skew CDR content towards a non-specific phenotype.
- How to increase antibody affinity without introducing unwanted charge.
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