Novel strategies for optimizing antibody stability and half-life
18 Nov 2024
Lead Identification & Optimization
- What are the key issues faced in the in vitro degradation of antibodies, and which (bio)chemical pathways contribute to their degradation ?
- How can we identify optimal formulation conditions for antibodies, considering factors such as pH, temperature, and the use of excipients ?
- What strategies can be employed to control and optimize the variability in glycosylation profiles of antibodies ?
- In what ways can protein engineering, such as Fc domain modifications, contribute to enhanced antibody stability and half-life ?
- How do antibodies interact with the immune system, and what mechanisms govern their clearance in vivo ?
Industry Expert
