Balancing linker stability to ensure controlled payload release without compromising ADC efficacy
28 Apr 2026
ADC Linker Design & Conjugation Technologies
- Optimization of Drug Antibody Conjugates: Defining DAR, linker kinetics and stability, structural features and compositional stoichiometry, and analytical robustness
- Identification of limitations to development: Optimization of high-resolution methods to obtain precise conjugation site information, quantification of site occupancy, and identification of post-translational modifications and effects of degradation under various conditions
- Collaborative approaches to ADC development: Rapid, just-in-time access to analytical platforms and scientific expertise, development of effective CQAs, robust, high-resolution production lot comparability
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