Integrating target biology and mechanism of action to minimize on-target adverse effects in healthy tissues
28 Apr 2026
Target Selection & Mechanisms of Action
- How can we address the challenge of candidate antigens being expressed in both diseased and healthy tissues to enhance selective targeting and minimize on-target toxicity?
- What strategies can improve tissue discrimination in single-target approaches to better differentiate diseased from normal tissues and reduce unintended engagement and safety risks?
- How do we align the therapeutic modality—whether cytotoxic, immune-activating, or inhibitory—with target biology to effectively mitigate mechanism of action-dependent safety risks?
