Target Selection & Mechanisms of Action topic: Resolving tissue-level mechanism of action through drug-inclusive spatial multiomics
28 Apr 2026
Target Selection & Mechanisms of Action
- Where does the therapeutic antibody — or the antibody component of an ADC — localize within complex tissue?
- Does the antibody reach and engage the intended target cell population?
- For ADCs, where and to what extent is the cytotoxic payload released?
- Do antibody distribution and payload exposure remain spatially aligned?
- What cellular response follows target engagement (mAbs) or payload delivery (ADCs) in situ?
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