The PioneerTM Antibody Discovery Platform is Bio-Rad’s new service for biotherapeutic lead generation. The new Pioneer Antibody Library is central to the Discovery Platform. Its design is informed by over 18 years of experience in antibody phage display. It was engineered to have optimal properties for the selection of therapeutic antibody candidates, including the reduction of CDR-located posttranslational modification sites for improved developability. The Pioneer Platform delivers diverse high-affinity antibody lead candidates. Using anti-TIGIT antibodies as an example, we show that, for the parameters tested, the performance of our lead candidates is comparable with several antibodies currently undergoing clinical trials.