Overcoming membrane protein complexes using display technologies
23 Jun 2025
Target Selection & Mechanisms of Action
- What engineering strategies are used to enhance membrane antigen presentation, and why are they important?
- What are the key benefits and challenges of display-based screening methods, such as antibody libraries and sequence diversity sampling?
- How do early functional screening methods contribute to effective hit selection in antibody discovery?
- What is the role of lead optimization, and how does it refine antibody candidates post-hit selection?
- How can structure-based engineering, de novo protein design, and in vitro display be integrated to improve hit identification and optimization?
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