Enhancing antigen-specific binding affinity for improved clinical efficacy
23 Jun 2025
Target Selection & Mechanisms of Action
- What are some challenges in affinity maturation of antibodies against membrane proteins and how have you tackled them?
- Balancing affinity, specificity, and TMDD—have you rescued a high-affinity binder from a target experiencing TMDD by engineering pH-dependent binding?
- How do you measure off-target binding, and what approaches have you employed to increase on-target affinity while reducing non-specificity?
Industry Expert
