Target selection to avoid off-target effect and cross-reactivity with healthy tissues
23 Jun 2025
Target Selection & Mechanisms of Action
- What characteristics make a protein a “clean” target in terms of avoiding the off-target effects of a therapeutic antibody?
- What can we do to minimize antibody cross-reactivity during the discovery stage for developing highly specific antibody drugs?
- According to the progress achieved so far, to what extent can format-based drug design contribute to decreasing off-target safety concerns?
- Can you discuss a real-world example where poor targeting led to severe off-target effects in non/clinical development stages?
Industry Expert
