Challenging membrane antibody targets: Brainstorming in-parallel in vivo and in vitro methodologies to identify rare and precious functional Ab candidates
17 Jun 2024
Salon F
Emerging Technologies
- Antigen generation is critical for the success of any antibody discovery project but especially challenging for membrane proteins. What antigen generation approaches have you found most effective? How successful were the different antigen generated for in vitro vs in vivo discovery strategies?
- What screening strategies are most effective to identify the rare functional antibodies? Cell-based assays? Droplet microfluidics?
- What optimization strategies are successful once hit has been identified?
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