Overcoming the downstream processing challenges of high-concentration antibodies
01 Sept 2026
Downstream Processing & Purification
- How can increased viscosity be managed to minimise its impact on pumping, mixing, filtration and process transfers?
- What strategies can maintain acceptable flux and product recovery during ultrafiltration and diafiltration of high-concentration antibodies?
- How does increasing antibody concentration affect mass transfer, membrane fouling and chromatography performance?
- How can aggregation, precipitation and particle formation be prevented during concentration and buffer exchange?
- How can the demand for high-concentration drug products be balanced with manufacturability, processing time and overall product yield?