Cell line development strategies towards overcoming multispecific expression challenges
01 Sept 2026
Cell Line Development
- How do we get CHO cells to express and correctly assemble multispecific antibodies with the intended structure?
- How do we steer CHO to achieve the right balance of titer, product quality, and minimize product related impurities?
- Are some multispecifics so complex in structure that we have to build different expression vector designs?
- Is it still possible to have a platform for CHO cell line development?
- What is the impact to our timelines? Are we having to build in extra time for developability screens?
- How is cell line characterization more challenging for multispecifics?
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