Identifying conditions that trigger denaturation or chemical modifications
29 Apr 2026
Formulation & Stability
- Which formulation conditions (pH, ionic strength, excipients) most strongly trigger protein denaturation or chemical modification?
- How do environmental stresses such as temperature, light, agitation, or freeze–thaw cycles accelerate degradation pathways?
- What analytical methods are most effective for detecting early signs of denaturation or chemical change?
- How can stress studies be designed to distinguish reversible unfolding from irreversible chemical modifications?
- Which formulation strategies best mitigate identified degradation risks while maintaining manufacturability and shelf life?