Balancing productivity with quality: Are we reaching the limits of cell line optimisation?
29 Apr 2026
Cell Line Development
- Are current cell line optimisation strategies approaching their biological or technological limits?
- How does pushing for higher productivity impact product quality attributes such as glycosylation and stability?
- What trade-offs emerge between yield, consistency, and regulatory compliance as productivity increases?
- Can emerging tools (e.g., systems biology or AI-guided design) overcome current optimisation bottlenecks?
- When does further cell line engineering deliver diminishing returns compared to process or formulation optimisation?