Separating aggregates and fragments without reducing yield or affecting stability
29 Apr 2026
Downstream Processing & Purification
- How can optimized chromatographic techniques such as SEC or IEX be employed to effectively distinguish aggregates, fragments, and monomers while maintaining high resolution and recovery rates?
- How can real-time dynamic light scattering (DLS) monitoring be implemented to track particle size and enable early detection and control of aggregate formation?
- How can high-performance ultrafiltration membranes with precise molecular weight cut-offs be used to remove aggregates and fragments without compromising product yield?
- How can advanced formulation strategies incorporating stabilizers or excipients improve protein stability and reduce aggregation or fragmentation during purification?
