Applying omic data analytics to predict personalized drug response holds significant promise, yet translating complex biological signals into reliable predictions remains challenging. This poster explores how genomic, transcriptomic, proteomic, and clinical data can be integrated to model patient level drug response. Key challenges include data heterogeneity, limited patient matched datasets, and variability across disease states and treatment contexts. The discussion will examine model robustness, validation strategies, and the balance between population level trends and individual response prediction. Emphasis will be placed on improving predictive confidence, clinical relevance, and the practical application of omic driven models in drug development.