As demand for cell-based therapies grows, scalable manufacturing solutions are essential. The Quantum Flex® Cell Expansion System and FINIA® Fill and Finish System are next-generation tools enabling consistent, high-quality production of MSCs and CAR-T cells. We demonstrate an integrated, functionally closed solution automating >200-fold CAR-T expansion from minimal input while maintaining high viability and consistent final product fill volumes, streamlining production and reducing operator burden. The system also supports robust MSC expansion using GMP-grade fibronectin, demonstrating versatility across cell types. Together, these flexible technologies accelerate cell therapy manufacturing and broaden patient access.