Advancing Purity in AAV Gene Therapy: Strategies for Minimizing and Clearing Empty Capsids
18 Sep 2025
Gene Therapy CMC & Process Development
- Challenges posed by product-related impurities like empty capsids on safety, efficacy, and regulatory expectations.
- Emerging technologies and process controls that enhance full-to-empty capsid ratios during AAV production.
- Approaches to selectively clear empty capsids while preserving yield and ensuring downstream purity
