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Addressing an important challenge faced: How can we enhance AAV, LV, and non-viral delivery technologies to increase efficiency, tissue targeting, and reduce immunogenicity?

04 May 2026
Gene Therapy Development
  • AAV: How can capsid engineering improve tissue tropism, reduce immunogenicity, and enhance transduction efficiency?
  • What are the key challenges in achieving specificity in targeted non-viral gene therapy delivery?
  • How can product quality assessment and impurity characterization help identify immunogenicity and toxicity risks at an early stage?
  • What strategies are being developed to create immune-evasive lipid nanoparticle (LNP) formulations?
  • Non-viral: How can LNP composition (ionizable lipids, helper lipids, and PEG-lipids) and formulation parameters be optimized to improve delivery performance?
Industry Expert
Yan Gu, Director, CMC Project Leader - Sanofi